期刊
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
卷 31, 期 8, 页码 1436-1440出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.urolonc.2012.03.002
关键词
Active surveillance; Prostate volume; PSA density; MRI; Transrectal ultrasound
Objectives: To compare prostate volume obtained by transrectal ultrasound (TRUS) and endorectal MRI (eMRI) to assess the reliability of TRUS in determining prostate-specific antigen (PSA) density. Materials and methods: Data for 2,410 patients diagnosed with localized prostate cancer (CaP) and treated with radical retropubic prostatectomy (RRP) at the University of Pennsylvania Health System between 1991 and 2005 was reviewed. Of these patients, 756 had both a preoperative TRUS and eMRI of the prostate performed. Prostate size was estimated using the prolate ellipsoid formula (height X width X length x pi/6); maximal height or antero-posterior (A-P) diameter was determined using a midsagittal view for TRUS and an axial view for eMRI. Pearson's correlation, linear regression, and paired t-test were performed to compare prostate volumes estimated via both imaging modalities. Results: Average prostate size measured with TRUS and eMRI correlated significantly with one another (R = 0.801; P < 0.0001), demonstrating a strong linear relationship (y = 0.891x + 2.622, R-2 = 0.642). Comparison of PSA density also demonstrated a strong linear relationship (y = 0.811x + 0.053, R-2 = 0.765). Average prostate volume differed by 1.7 ml (TRUS relative to eMRI), which was statistically significant based on a paired t-test (P < 0.001). Upon stratification of patients into three groups based on average TRUS volume (<= 30, >30-60, and >60 ml), significant correlation (0.318, 0.564, 0.650) and difference between volumes (-2.1, 4.0, 5.1 ml; P < 0.0001, P < 0.0001, P < 0.05 TRUS relative to eMRI) was maintained. Conclusions: Prostate volume estimations with TRUS and eMRI are highly correlated. It is therefore, reasonable to conclude that in the hands of an experienced sonographer, TRUS is not only an efficient and economical examination, but also an accurate and reproducible modality to estimate prostate size. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据