期刊
AUSTRALIAN JOURNAL OF CHEMISTRY
卷 68, 期 9, 页码 1373-1378出版社
CSIRO PUBLISHING
DOI: 10.1071/CH15169
关键词
-
资金
- ARC Discovery Project [DP150103522]
- NHMRC Project [APP1029878, APP1008106]
- Victorian Government's Operational Infrastructure Support Program
- University of Melbourne for a MIRS PhD award
A series of N- and C-terminal modifications of the monomeric proline-rich antimicrobial peptide, Chex1-Arg20, was obtained via different chemical strategies using Fmoc/tBu solid-phase peptide synthesis in order to study their effects on a panel of Gram-negative bacteria. In particular, C-terminal modifications with hydrazide or alcohol functions extended their antibacterial activity from E. coli and K. pneumoniae to other Gram-negative species, A. baumannii and P. aeruginosa. Furthermore, these analogues did not show cytotoxicity towards mammalian cells. Hence, such modifications may aid in the development of more potent proline-rich antimicrobial peptides with a greater spectrum of activity against Gram-negative bacteria than the parent peptide.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据