期刊
UROLOGIA INTERNATIONALIS
卷 87, 期 1, 页码 49-53出版社
KARGER
DOI: 10.1159/000325880
关键词
Prostate cancer; Magnetic resonance imaging; Prostate biopsy; Negative predictive value; Positive predictive value; Likelihood ratio
资金
- Medical Research Council, Pelican Cancer Foundation, Prostate UK
- St Peter's Trust
- Prostate Cancer Research Foundation
- Prostate Cancer Research Centre
- UCL/UCLH NIHR Comprehensive Biomedical Research Centre
- GSK
- USHIFU/Focused Surgery/Misonix Inc.
- Medical Research Council [G0701302, G1002509] Funding Source: researchfish
- National Institute for Health Research [09/22/67] Funding Source: researchfish
- MRC [G0701302, G1002509] Funding Source: UKRI
Objectives: Overdiagnosis is arguably the greatest challenge in the management of men with prostate cancer. Multi-parametric (mp)-MRI prior to prostate biopsy may have a role in ruling-in and ruling-out clinically significant disease. Patients and Methods: 114 consecutive men at risk of prostate cancer with previous biopsy underwent mp-MRI prior to transrectal ultrasound (TRUS)-guided biopsies. Standard systematic biopsies were carried out with targeting to suspicious areas. Results: 59.6% had cancer detected by TRUS-guided biopsy. Mean age was 63.6 years (SD 9.0). If men had not been biopsied because of a negative mp-MRI, 21% (24/114) with no cancer and 5% (6/114) with clinically insignificant cancer could have avoided a biopsy. However, 4% (4/114) would have been advised to defer a biopsy that demonstrated the presence of clinically significant cancer. Conclusion: mp-MRI may have a role in ruling-in and ruling-out clinically significant prostate cancer in men at risk prior to biopsy. Copyright (C) 2011 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据