期刊
UPSALA JOURNAL OF MEDICAL SCIENCES
卷 119, 期 2, 页码 142-148出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/03009734.2014.903323
关键词
Antibiotic resistance; fitness; intervention
Although theoretically attractive, the reversibility of resistance has proven difficult in practice, even though antibiotic resistance mechanisms induce a fitness cost to the bacterium. Associated resistance to other antibiotics and compensatory mutations seem to ameliorate the effect of antibiotic interventions in the community. In this paper the current understanding of the concepts of reversibility of antibiotic resistance and the interventions performed in hospitals and in the community are reviewed.
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