期刊
ULTRASTRUCTURAL PATHOLOGY
卷 33, 期 1, 页码 6-15出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/01913120802608430
关键词
alpha-smooth muscle actin; fibronectin; myofibroblast; osteopontin; tenascin-C
资金
- Academy of Finland
- Jalmari and Rauha Ahokas Foundation
- Finnish Anti-Tuberculosis Association Foundation
Fibroblast differentiation into myofibroblast in transforming growth factor-beta1-exposed human lung fibroblasts and the immunolocalizations of alpha-smooth muscle actin, fibronectin, tenascin-C, and osteopontin in exposed cells were studied by conventional transmission electron microscopy and immunoelectron microscopy. Ultrastructural features of myofibroblasts were detected after exposure, e.g., alpha-smooth muscle actin positive bundles in the cytoplasm of cells and extracellular fibronectin-containing structures on the surface of the cell forming fibronexus structure, osteopontin adjacent to rough endoplastic reticulum and extracellular tenascin-C in the vicinity of the cell. The authors concluded that exposure to transforming growth factor-beta1 can differentiate lung fibroblasts into ultrastructurally typical myofibroblasts.
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