期刊
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
卷 41, 期 2, 页码 216-222出版社
WILEY
DOI: 10.1002/uog.11226
关键词
anti-Mullerian hormone; folliculogenesis; FSH; intracycle; ovarian reserve; three-dimensional; ultrasound; variation
Objective To quantify the intracycle variation in markers of ovarian reserve measured by antral follicle counts stratified by size using three-dimensional (3D) ultrasound and anti-Mullerian hormone (AMH) in women with normal menstrual cycles. Methods Healthy volunteers with normal menstrual cycles were prospectively recruited. Three-dimensional (3D) ultrasound examination and blood test were performed in early (F1) and mid-follicular (F2) phases and in periovulatory (PO) and luteal (LU) phases of one menstrual cycle. Antral follicles were measured using sonography-based automated volume calculation' with post processing (SonoAVC) and ovarian volume was measured using Virtual Organ Computer-aided AnaLysis (VOCAL). Blood serum was processed for hormonal assays including AMH, follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol. Repeated-measures analysis was used to examine the variance in markers of ovarian reserve in different phases of one menstrual cycle. Results A total of 36 volunteers were included in the final analysis, of whom 34 attended all four visits. Repeated-measures analysis showed a significant variation in total antral follicle count (AFC) (P<0.001). However, on stratifying the antral follicles according to size using SonoAVC, a non-significant variation (P=0.382) was seen in small AFC ( 6.0 mm) and a significant variation (P<0.001) was seen in large AFC (> 6.0 mm). The ovarian volume showed a significant intracycle variation (P<0.001). A small but significant intracycle variation was noted in AMH (P=0.041) and a significant variation was seen in levels of serum FSH, LH and estradiol (P<0.05). Conclusion Small antral follicles ( 6.0 mm) measured using 3D ultrasound and AMH show little intracycle variation and perhaps should be evaluated when predicting ovarian reserve independent of menstrual cycle.
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