期刊
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
卷 38, 期 2, 页码 179-184出版社
WILEY
DOI: 10.1002/uog.8903
关键词
aortic isthmus; Doppler; ductus venosus; intrauterine growth restriction; myocardial performance index
资金
- Fondo de Investigacion Sanitaria (Spain) [PI/060347]
- Cerebra Foundation
- Thrasher Research Fund (Salt Lake City, USA)
- Marie Curie Host Fellowships for Early Stage Researchers [FETAL-MED-019707-2]
- Juan de la Cierva
- Fondo de Investigaciones Sanitarias, Spain
- Mexican National Council for Science and Technology (CONACyT), in Mexico City
Objective To explore the sequence of changes in myocardial performance index (MPI) and aortic isthmus (AoI) and ductus venosus (DV) flow in fetuses with early-onset intrauterine growth restriction (IUGR). Methods MPI and AoI and DV pulsatility indices (PI) were evaluated every 1-7 days in a cohort of IUGR fetuses with abnormal umbilical artery Doppler PI (> 95(th) percentile) delivered before 34 weeks' gestation. The longitudinal changes were analyzed in the last 30 days before delivery by multilevel and survival analysis. Results A total of 430 scans were performed on 115 IUGR fetuses. MPI, AoI-PI and DV-PI showed increases with the progression of fetal deterioration throughout the follow-up study period, but the rates of progression were different. On average, MPI, AoI-PI and DV-PI crossed the 95th percentile at 26 days, 12 days and 5 days before delivery, respectively. At the last examination before delivery, the proportion of increased MPI (70.4%) was significantly higher than that of abnormal AoI-PI (55.7%; P < 0.01) and DV-PI (47.8%; P < 0.01). Conclusion In early-onset IUGR, MPI and AoI and DV Doppler indices all increase but at different rates, which could provide the basis for further research on their use for improving in-utero monitoring and prediction of long-term outcome. Copyright (C) 2011 ISUOG. Published by John Wiley & Sons, Ltd.
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