期刊
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
卷 34, 期 3, 页码 249-252出版社
WILEY
DOI: 10.1002/uog.7329
关键词
first trimester; nuchal translucency; prenatal diagnosis; spina bifida; ultrasound
Objective Prenatal diagnosis of open spina bifida is carried out by ultrasound examination in the second trimester of pregnancy. The diagnosis is suspected by the presence of a 'lemon-shaped' bead and a 'banana-shaped' cerebellum, thought to be consequences of caudal displacement of the hindbrain. The aim of the study was to determine whether in fetuses with spina bifida this displacement of the brain is evident from the first trimester of pregnancy. Methods In women undergoing routine ultrasound examination at 11-13 weeks' gestation as part of screening for chromosomal abnormalities, a mid-sagittal view of the fetal face was obtained to measure nuchal translucency thickness and assess the nasal bone. In this view the fourth ventricle, which presents as an intracranial translucency (IT) between the brain stein and choroid plexus, is easily visible. We measured the anteroposterior diameter of the fourth ventricle in 200 normal fetuses and in four fetuses with spina bifida. Results In the normal fetuses the fourth ventricle was always visible and the median anteroposterior diameter increased from 1.5 mm at a crown-rump length (CRL) of 45 mm to 2.5 mm at a CRL of 84 mm. In the four fetuses with spina bifida the ventricle was compressed by the caudally displaced hindbrain and no IT could be seen. Conclusion The mid-sagittal view of the face as routinely used in screening for chromosomal defects can also be used for early detection of open spina bifida. Copyright (C) 2009 ISUOG. Published by John Wiley & Sons, Ltd.
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