期刊
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
卷 32, 期 7, 页码 871-876出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/uog.6126
关键词
Doppler; FMD; PIGF; pre-eclampsia; sEng
资金
- Fetal Medicine Foundation (UK)
Objectives To determine whether maternal serum concentrations of placental growth factor (PIGF) and soluble endoglin (sEng) are altered in women who subsequently develop pre-eclampsia (PE) or have small-for-gestational-age (SGA) infants, and whether these changes are associated with maternal endothelial dysfunction. Methods Maternal serum PIGF and sEng were measured in two groups of pregnant women at 23-25 weeks' gestation: Group A (n = 40), with normal uterine artery Doppler waveforms and Group B (n = 43) with abnormal Doppler. Maternal endothelial dysfunction was assessed by flow-mediated dilatation (FM D) of the brachial artery. Comparisons between groups were performed using one-way analysis of variance. Results In Group B, 16 women had normal outcome, 15 delivered SGA infants and 12 developed PE. Women who developed PE bad lower levels of PIGF (154.8 +/- 150.8 vs. 423.3 +/- 230.5 pg/mL; P < 0.001) (data given as mean +/- SD) and higher levels of sEng (8.1 (7.0-14.1) vs. 6.5 (4.9-7.9) pg/mL; P < 0.05) (data given as median (interquartile range)) than Group A. Similar were the findings in women who delivered SGA infants. In women who subsequently developed PE, there was no correlation between FMD and either PIGF or sEng. Conclusions Maternal serum concentrations of PIG F and sEng are altered in women who develop PE. However, these alterations do not correlate directly with maternal endothelial dysfunction. Copyright (C) 2008 ISUOG. Published by John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据