期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 40, 期 4, 页码 704-713出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2013.10.016
关键词
Fatty liver disease; Steatosis; Dispersion; Crawling waves; Shear wave elasticity imaging; Medical ultrasound imaging; Viscoelastic tissue models
资金
- University of Rochester Department of Electrical & Computer Engineering
- University of Rochester Medical Center Departments of Surgery, Radiology, Biostatistics & Computational Biology and Pathology & Laboratory Medicine
The accumulation of fat droplets within the liver is an important marker of liver disease. This study assesses gradations of steatosis in mouse livers using crawling waves, which are interfering patterns of shear waves introduced into the liver by external sources. The crawling waves are detected by Doppler ultrasound imaging techniques, and these are analyzed to estimate the shear wave speed as a function of frequency between 200 and 360 Hz. In a study of 70 mice with progressive increases in steatosis from 0% to >60%, increases in steatosis are found to increase the dispersion, or frequency dependence, of shear wave speed. This finding confirms an earlier, smaller study and points to the potential of a scoring system for steatosis based on shear wave dispersion. (E-mail: kevin.parker@rochester.edu) (C) 2014 World Federation for Ultrasound in Medicine & Biology.
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