期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 39, 期 7, 页码 1197-1206出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2013.01.020
关键词
Crohn's disease; Inflammatory bowel disease; Intestinal blood flow; Ultrasonography
资金
- Medviz, an inter-disciplinary research cluster at Haukeland University Hospital
- University of Bergen
- Christian Michelsen Research AS
- Czech Science Foundation [GA102/12/2380]
- European Regional Development Fund (Project FNUSA-ICRC) [CZ.1.05/1.1.00/02.0123]
The aim of this study was to determine whether there are differences in absolute blood flow between patients with Crohn's disease with inflammation or fibrosis using contrast-enhanced ultrasound. Eighteen patients with fibrotic disease and 19 patients with inflammation were examined. Video sequences of contrast data were analyzed using a pharmacokinetic model to extract the arterial input and tissue residue functions with a custom software, enabling calculation of the absolute values for mean transit time, blood volume and flow. Feasibility of the examination was 89%. The fibrosis group had lower blood volume (0.9 vs. 3.4 mL per 100 mL tissue; p = 0.001) and flow (22.6 vs. 45.3 mL/min per 100 mL tissue; p = 0.003) compared with the inflammation group. There was no significant difference in mean transit time (3.9 vs. 5.5 s). In conclusion, absolute perfusion measurement in the gastrointestinal wall using contrast-enhanced ultrasound is feasible. There seems to be reduced blood volume and blood flow in patients with fibrotic disease. (E-mail: mpkkn@med.uib.no or kimnylund1@gmail.com) (c) 2013 World Federation for Ultrasound in Medicine & Biology.
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