期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 39, 期 7, 页码 1223-1232出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2013.02.002
关键词
Quantitative ultrasound; Axial transmission; Guided waves; Cortical bone; Osteoporosis
资金
- Academy of Finland [135211, 133183]
- National Natural Science Foundation of China [11174060]
- PhD Programs Foundation of the Ministry of Education of China [20110071130004]
- New Century Excellent Talents of the Ministry of Education of China [NCET-10-0349]
- Academy of Finland (AKA) [133183, 135211, 133183, 135211] Funding Source: Academy of Finland (AKA)
The fundamental flexural guided wave (FFGW), as modeled, for example, by the A0 Lamb mode, is a clinically useful indicator of cortical bone thickness. In the work described in this article, we tested so-called multiridge-based analysis, based on the crazy climber algorithm and short-time Fourier transform, for assessment of the FFGW component recorded by a clinical array transducer featuring a limited number of elements. Methods included numerical finite-element simulations and experiments in bone phantoms and human radius specimens (n = 41). The proposed approach enabled extraction of the FFGW component and determination of its group velocity. This group velocity was in good agreement with theoretical predictions and possessed reasonable sensitivity to cortical width (r(2) = 0.51, p < 0.001) in the in vitro experiments. It is expected that the proposed approach enables related clinical application. Further work is still needed to analyze in more detail the challenges related to the impact of the overlying soft tissue. (E-mail: warma@iki.fi) (C) 2013 World Federation for Ultrasound in Medicine & Biology.
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