期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 38, 期 9, 页码 1618-1625出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2012.04.020
关键词
Ultrasound; Muscle; Myopathy; Backscatter; Reliability; Quantitative; Children; Adults
资金
- Washington University Neuromuscular Research Fund
- National Institute of Health Neurological Sciences Academic Development Award Grant [K12 NS00169009]
- Institute of Clinical and Translational Sciences
- National Center for Research Resources Grant [UL1 RR024992]
Widespread implementation of quantitative muscle ultrasonography in assessing skeletal muscle pathology is limited by an inability to replicate results between different ultrasound systems. We have developed a measurement of skeletal muscle pathology, calibrated muscle backscatter (cMB), which should be reproducible between different ultrasound systems. We compared the reliability of grayscale and cMB measurements between different ultrasound systems, configurations and region-of-interest (ROI) sizes. cMB of skeletal muscle was reliably measured (intraclass correlation coefficient [ICC] <= 0.98) despite very dissimilar grayscale levels (ICC <= 0.54). cMB reliability was highest between systems using similar settings (ICC: 0.82-0.98) and was lowest when transducer type varied (ICC: 0.47-0.71). Reliability was better from ROIs spanning a narrow range of depths compared with larger ranges. cMB measurements are more reliable than grayscale between different ultrasound systems and configurations. Measuring cMB could improve widespread implementation of quantitative ultrasound in assessments of skeletal muscle pathology. (E-mail: zaidmanc@neuro.wustl.edu) (c) 2012 World Federation for Ultrasound in Medicine & Biology.
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