期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 37, 期 10, 页码 1635-1643出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2011.06.014
关键词
Ultrasound; Fractured bone healing; New bone growth; Torsional stiffness
资金
- National Science Council, Taiwan, Republic of China [NSC 99-2120-M-038 -001, NSC 99-2627-B-033 -001]
This study investigated the effects of ultrasound (US) at different frequencies on fracture healing over a three-week period in a rabbit fibular fracture model. Forty-five adult New Zealand White rabbits were divided into five groups: a control group and four groups treated with US frequencies of 0.5, 1.0, 1.5 and 2.0 MHz (0.5 W/cm(2), 200-mu s burst, pulsed 1: 4). After anesthesia, transverse osteotomy was performed on the fibula bone. This was followed by intravital staining and fluorescence microscopic examination of new bone formation and biomechanical tests of torsional stiffness at the osteotomy site. Results showed that total new bone formation and torsional stiffness of the fibula were greater in all US-treated groups than in the control group. No significant difference was found between any of the four US-treated groups. The US treatment also enhanced bone growth of the sham-treated contralateral fracture site. These results suggest that US treatment at 0.5, 1.0, 1.5 or 2.0 MHz can enhance fracture healing in a rabbit model. Furthermore, the effects of US on fracture healing at present parameters might not be confined locally. (E-mail: whchang@cycu.edu.tw) (C) 2011 World Federation for Ultrasound in Medicine & Biology.
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