期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 34, 期 9, 页码 1449-1464出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2008.02.004
关键词
thermal ablation; ultrasound treatment monitoring; tissue characterization; ultrasonic signal processing; ultrasound thermometry
资金
- U.S. Army MRMC/TATRC [DAMD 17-002-0063, DAMD 17-02-2-0014]
- Office of Naval Research [N00014-01-G-0460]
- NIH-NCI [R01 CA109557-01]
Previously, noninvasive methods of estimating local tissue thermal and acoustic properties using backscattered ultrasound have been proposed in the literature. In this article, a noninvasive method of estimating local thermal diffusivity in situ during focused ultrasound heating using beamformed acoustic backscatter data and applying novel signal processing techniques is developed. A high intensity focused ultrasound (HIFU) transducer operating at subablative intensities is employed to create a brief local temperature rise of no more than 10 degrees C. Beamformed radio-frequency (RF) data are collected during heating and cooling using a clinical ultrasound scanner. Measurements of the time-varying acoustic strain, that is, spatiotemporal variations in the RF echo shifts induced by the temperature related sound speed changes, are related to a solution of the heat transfer equation to estimate the thermal diffusivity in the heated zone. Numerical simulations and experiments performed in vitro in tissue mimicking phantoms and excised turkey breast muscle tissue demonstrate agreement between the ultrasound derived thermal diffusivity estimates and independent estimates made by a traditional hot-wire technique. The new noninvasive ultrasonic method has potential applications in thermal therapy planning and monitoring, physiological monitoring and as a means of noninvasive tissue characterization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据