期刊
ULTRASONICS SONOCHEMISTRY
卷 18, 期 2, 页码 652-660出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ultsonch.2010.08.009
关键词
Power ultrasound; 4-Hydroxycoumarin; Hantzsch dihydropyridine; Reaction on water; Tandem Knoevenagel-reductive Michael; addition reaction
资金
- Ministero dell'Istruzione, dell'Universita e della Ricerca
3-(Aryl)methyl-4-hydroxycoumarins were produced in good to excellent yields by reaction between 4-hydroxycoumarin and (hetero)aromatic aldehydes in the presence of Hantzsch 1,4-dihydropyridine (HEH) which works as an hydride donor (i.e., in a sequential Knoevenagel-reductive Michael addition). The sonochemical-assisted procedure (method B) provides an improved and accelerated conversion when compared to conventional silent reactions (method A). Experiments carried out according to method B showed that the reaction could be more efficiently run in the absence of organic solvents, at 30-40 degrees C in open vessel, without the need of an excess HEN and with simplified work-up and separation procedures. (C) 2010 Elsevier B.V. All rights reserved.
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