期刊
ULTRASONICS SONOCHEMISTRY
卷 16, 期 3, 页码 312-315出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ultsonch.2008.10.012
关键词
Sonochemistry; Steroid analogous; Alkylation; Cycloaddition; Ultrasound
资金
- CEEX [49/2005]
- CNCSIS [Td-12/2008]
A new, fast, efficient and general method for preparation of steroid analogous of anticipated biological activity under ultrasound irradiation and classical heating is reported. The reaction pathway involves two steps: quaternization of phthalazine heterocycle followed by a 3+2 dipolar cycloaddition of cycloimmonium ylides to dienophiles. Under ultrasound the reaction time decreases substantially, the yields are higher, the reaction conditions are milder. A comparative study ultrasound verses classical heating has been done. (c) 2008 Elsevier B.V. All rights reserved.
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