期刊
TWIN RESEARCH AND HUMAN GENETICS
卷 16, 期 1, 页码 157-162出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/thg.2012.142
关键词
twins; families; cohort studies; longitudinal; database
资金
- Academy of Finland Center of Excellence in Complex Disease Genetics [213506, 129680]
- Academy of Finland [100499, 205585, 118555, 141054]
- Global Research Awards for Nicotine Dependence (GRAND)
- European Network for Genetic and Genomic Epidemiology (ENGAGE), FP7-HEALTH-F4-2007 [201413]
- NIH [DA12854, AA12502, AA00145, AA09203, AA15416]
- Sanger Institute
- Nordic Cancer Union
- The Finnish Cancer Society
- Sigrid Juselius Foundation
- The Jenny and Antti Wihuri Foundation
In 2002 and 2006, review papers have described the Finnish Twin Cohort and studies conducted on these population-based, longitudinal data sets with extensive follow-up data. Three cohorts have been established: the older twin cohort in the 1970s, and the Finntwin12 and Finntwin16 studies initiated in the 1990s. The present review provides on update on the latest data collections conducted since the previous review. These cover the fourth waves of data collection in the older cohort (twins born before 1958) and Finntwin12 (twins born 1983-1987). The fifth wave of data collection in Finntwin16 (twins born 1975-1979) also included assessments of their spouses/partners. An analysis of mortality in the older cohort from 1975 to 2009 indicates that the mortality of adult twins (as individuals) does not differ from the population at large. Based on the cohorts, many sub-studies with more detailed phenotyping and collection of omics data have been conducted or are in progress. We also contribute to numerous national and international collaborations.
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