期刊
TWIN RESEARCH AND HUMAN GENETICS
卷 16, 期 1, 页码 317-329出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/thg.2012.104
关键词
population-based; twin; registry; biobank; Sweden
资金
- Ministry for Higher Education
- TwinGene
- Swedish Research Council [M-2005-1112, 20113060, K2006-71X-14676-04-2, 2008-54x20638-01-3]
- GenomEUtwin [EU/QLRT-2001-01254, QLG2-CT-2002-01254]
- NIH [DK U01-066134]
- Swedish Foundation for Strategic Research (SSF)
- Heart and Lung foundation [20070481. STOPPA]
- Strategic Research Program in Epidemiology at Karolinska Institutet
- Swedish Asthma and Allergy Association
- Stockholm County Council
- Karolinska Institutet
- Swedish Council for Working Life and Social Research
- Swedish Research Council
- Systembolaget
- National Board of Forensic Medicine
- Swedish Prison and Probation Service
- Bank of Sweden Tercentenary Foundation
- Soderstrom-Konigska foundation
- Karolinska Institutet Center of Neurodevelopmental Disorders (KIND).
- Swedish Council for Working Life and Social Research [2004-0174, 2007-0231]
- Swedish Cancer Society [4594-B01-01XAC, 4594-B04-04XAB]
- European Union [FP6 036894]
The Swedish Twin Registry (STR) today contains more than 194,000 twins and more than 75,000 pairs have zygosity determined by an intra-pair similarity algorithm, DNA, or by being of opposite sex. Of these, approximately 20,000, 25,000, and 30,000 pairs are monozygotic, same-sex dizygotic, and opposite-sex dizygotic pairs, respectively. Since its establishment in the late 1950s, the STR has been an important epidemiological resource for the study of genetic and environmental influences on a multitude of traits, behaviors, and diseases. Following large investments in the collection of biological specimens in the past 10 years we have now established a Swedish twin biobank with DNA from 45,000 twins and blood serum from 15,000 twins, which effectively has also transformed the registry into a powerful resource for molecular studies. We here describe the main projects within which the new collections of both biological samples as well as phenotypic measures have been collected. Coverage by year of birth, zygosity determination, ethnic heterogeneity, and influences of in vitro fertilization are also described.
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