期刊
TWIN RESEARCH AND HUMAN GENETICS
卷 16, 期 1, 页码 144-149出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/thg.2012.89
关键词
twin studies; genetic epidemiology; longitudinal studies; genome-wide association studies; next-generation sequencing; genomics; epigenomics; gene expression analysis; metabolomics; microbiomics
资金
- Wellcome Trust
- Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre
- St Thomas' NHS Foundation Trust
- King's College London/Arthritis Research Campaign/EC [512066 (LSHG-CT-2004)]
- MOLPAGE/EC [200800]
- Treat OA/EC [Health-2007-A]
- ENGAGE/EC [Health-2007-2.4.5-4]
- GEFOS/EC [MRTN-CT-2006-034021]
- MyEuropia Research Training Network/Chronic Disease Research Foundation (CDRF)/Pfizer Pharmaceuticals/National Health
- Medical Research Council (NHMRC)/National Institute of Aging (NIA)/Guide Dogs for the blind Association (GDBA)/Biotechnology and Biological Sciences Research Council (BBSRC)
- National Eye Institute via an NIH/CIDR [R01EY018246-01-1]
- National Institute for Health Research [SRF/01/010] Funding Source: researchfish
TwinsUK is a nation-wide registry of volunteer twins in the United Kingdom, with about 12,000 registered twins (83% female, equal number of monozygotic and dizygotic twins, predominantly middle-aged and older). Over the last 20 years, questionnaire and blood/urine/tissue samples have been collected on over 7,000 subjects, as well as three comprehensive phenotyping assessments in the clinical facilities of the Department of Twin Research and Genetic Epidemiology, King's College London. The primary focus of study has been the genetic basis of healthy aging process and complex diseases, including cardiovascular, metabolic, musculoskeletal, and ophthalmologic disorders. Alongside the detailed clinical, biochemical, behavioral, and socio-economic characterization of the study population, the major strength of TwinsUK is availability of several 'omics' technologies for the participants. These include genome-wide scans of single nucleotide variants, next-generation sequencing, exome sequencing, epigenetic markers (MeDIP sequencing), gene expression arrays and RNA sequencing, telomere length measures, metabolomic profiles, and gut flora microbiomics. The scientific community now can freely access parts of the phenotype data from the 'TwinsUK', and interested researchers are encouraged to contact us via our Web site (www.twinsuk.ac.uk) for future collaborations.
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