期刊
BIOMATERIALS SCIENCE
卷 3, 期 2, 页码 246-249出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4bm00297k
关键词
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资金
- EPSRC
- EPSRC [EP/I004912/1, EP/I004998/1] Funding Source: UKRI
- Cancer Research UK [15565] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/I004912/1, EP/I004998/1] Funding Source: researchfish
Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.
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