期刊
BIOMATERIALS SCIENCE
卷 3, 期 5, 页码 733-741出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5bm00053j
关键词
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资金
- University of Southampton
- Royal Society
- EPSRC [EP/K503575/1, EP/J016918/1]
- Engineering and Physical Sciences Research Council [EP/K503575/1, EP/J016918/1] Funding Source: researchfish
- EPSRC [EP/K503575/1, EP/J016918/1] Funding Source: UKRI
Careful design of nanoparticles plays a crucial role in their biomedical applications. It not only defines the stability of nanoparticles in a biological medium but also programs their biological functionality and specific interactions with cells. Here, an inorganic nanoparticulate system engineered to have a dual role as anti-angiogenic and hyperthermic agent is presented. The inorganic rod-shaped core is designed to strongly absorb near-infrared laser irradiation through the surface plasmon resonance and convert it into localized heat, while a peptide coating acts as an anti-angiogenic drug, altogether inhibiting vascular growth. The synergistic dual action provides an improved inhibition of the in vitro tumour angiogenesis, offering new possibilities for the development of nano-engineered anti-angiogenic drugs for therapies.
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