期刊
BIOMATERIALS SCIENCE
卷 3, 期 9, 页码 1270-1278出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5bm00186b
关键词
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资金
- National Natural Science Foundation of China [21173038, 21401013, 21301027]
- Natural Science Foundation and Science and Technology Development Planning of Jilin Province [20130522136JH, 20130521010JH, 20140520088JH]
- Program for New Century Excellent Talents in University [NCET-13-0720]
- Specialized Research Fund for the Doctoral Program of Higher Education [20132216120002]
- National Hi-Technology Research and Development Program (863 Program) [2013AA032204, 2014DFA31740]
- Jilin Provincial Key Laboratory of Micro-Nano Functional Materials (Northeast Normal University)
- Postdoctoral Science Foundation of China [2014M551155]
Multifunctional Fe3O4@polyacrylic acid/Au nanoclusters/zeolitic imidazolate framework-8 nanoparticles (Fe3O4@PAA/AuNCs/ZIF-8 NPs) integrating tri-modal cancer imaging (magnetic resonance, computed X-ray tomography and fluorescence imaging) and chemotherapy into a single system were fabricated by using a facile, mild and reproducible strategy. The obtained NPs possess many merits including ultra-high doxorubicin (DOX) loading capability (1.54 mg DOX per mg NPs), dual pH-responsive controlled drug release, tri-modal cancer imaging ability, facile magnetic separation and good biocompatibility. Importantly, the NPs exhibit low systematic toxicity and high antitumor therapy efficacy in vivo through tail vein injection. Furthermore, the achievement of in vitro tri-modal cancer cell imaging reveals the potential of Fe3O4@ PAA/AuNCs/ZIF-8 NPs for cancer diagnosis and visualized-synergistic therapy. Taken together, Fe3O4@ PAA/AuNCs/ZIF-8 NPs can be developed as a promising theranostic agent that combines multiple capabilities for cancer treatment.
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