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Dalit Barkan et al.
CANCER RESEARCH (2008)
Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment
Christina K. Augustine et al.
CANCER RESEARCH (2008)
Evolving role of uPA/uPAR system in human cancers
Kathleen Ass et al.
CANCER TREATMENT REVIEWS (2008)
TGFβ primes breast tumors for lung metastasis seeding through angiopoietin-like 4
David Padua et al.
CELL (2008)
The cell-cell adhesion molecule E-cadherin
F. van Roy et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-β1
Scott L. Kominsky et al.
CLINICAL & EXPERIMENTAL METASTASIS (2008)
Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds α5β1 Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study
Alejandro D. Ricart et al.
CLINICAL CANCER RESEARCH (2008)
Cathepsin D-Many functions of one aspartic protease
Petr Benes et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2008)
Temporal and spatial regulation of integrins during development
Christopher M. Meighan et al.
CURRENT OPINION IN CELL BIOLOGY (2008)
Inflammatory cytokines increase extracellular procathepsin D in permanent and primary endothelial cell cultures
Sabine Erdmann et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2008)
Contractile forces in tumor cell migration
Claudia Tanja Mierke et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2008)
L1-CAM in cancerous tissues
Nancy Gavert et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2008)
TNF: A master switch for inflammation to cancer
Gautam Sethi et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2008)
Matrix Metalloproteinase-9 Interplays with the IGFBP2-IGFII Complex to Promote Cell Growth and Motility in Astrocytomas
Sandrine Rorive et al.
GLIA (2008)
A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous Å6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer
Sharad A. Ghamande et al.
GYNECOLOGIC ONCOLOGY (2008)
E-selectin regulates gene expression in metastatic colorectal carcinoma cells and enhances HMGB1 release
Tegest Aychek et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Prognostic significance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer
Zheng-Sheng Wu et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
Yasushi Shintani et al.
JOURNAL OF CELL BIOLOGY (2008)
Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric brain tumor consortium study PBTC-012
Tobey J. MacDonald et al.
JOURNAL OF CLINICAL ONCOLOGY (2008)
Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme
David A. Reardon et al.
JOURNAL OF CLINICAL ONCOLOGY (2008)
Immune-mediated dormancy: an equilibrium with cancer
Michele W. L. Teng et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2008)
Carbamoylphosphonate matrix metalloproteinase inhibitors 6:: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor -: Synthesis and pharmacodynamic and pharmacokinetic analysis
Amnon Hoffman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Integrin-dependent translational control: Implication in cancer progression
Jun Chung et al.
MICROSCOPY RESEARCH AND TECHNIQUE (2008)
Up-regulation of Rho/ROCK signaling in sarcoma cells drives invasion and increased generation of protrusive forces
Daniel Roesel et al.
MOLECULAR CANCER RESEARCH (2008)
The seed and soil hypothesis revisited
Isaiah J. Fidler et al.
LANCET ONCOLOGY (2008)
Cancer-related inflammation
Alberto Mantovani et al.
NATURE (2008)
Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype
D. Oxmann et al.
ONCOGENE (2008)
Overexpression of tyrosine kinase B protein as a predictor for distant metastases and prognosis in gastric carcinoma
Yong Zhang et al.
ONCOLOGY (2008)
Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells
Angela Colmone et al.
SCIENCE (2008)
Reorganisation of the dendritic actin network during cancer cell migration and invasion
Danijela Vignjevic et al.
SEMINARS IN CANCER BIOLOGY (2008)
Mechanisms linking tumor cell-associated procoagulant function to tumor dissemination
Joseph S. Palumbo
SEMINARS IN THROMBOSIS AND HEMOSTASIS (2008)
Cysteine cathepsin proteases as pharmacological targets in cancer
Carmela Palermo et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis
John M. Pawelek et al.
NATURE REVIEWS CANCER (2008)
CNTO 95, a fully human anti αv integrin antibody, inhibits cell signaling, migration, invasion, and spontaneous metastasis of human breast cancer cells
Qiming Chen et al.
CLINICAL & EXPERIMENTAL METASTASIS (2008)
被撤回的出版物: Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of β1-integrin, ERK, and NF-κB (Retracted article. See vol. 295, pg. 15426, 2020)
Praveen Bhoopathi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer
Carlo V. Hojilla et al.
BREAST CANCER RESEARCH (2008)
Immune cells as mediators of solid tumor metastasis
David G. DeNardo et al.
CANCER AND METASTASIS REVIEWS (2008)
MMP-2 siRNA induced Fas/CD95-mediated extrinsic II apoptotic pathway in the A549 lung adenocarcinoma cell line
C. Chetty et al.
ONCOGENE (2007)
Distinct mechanisms of tumor invasion and metastasis
Mahmut Yilmaz et al.
TRENDS IN MOLECULAR MEDICINE (2007)
The roles of proteolytic enzymes in the development of tumour-induced bone disease in breast and prostate cancer
Julia K. L. Woodward et al.
BONE (2007)
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
Cedric Gaggioli et al.
NATURE CELL BIOLOGY (2007)
Nanomechanical analysis of cells from cancer patients
Sarah E. Cross et al.
NATURE NANOTECHNOLOGY (2007)
Targeting selectins and selectin ligands in inflammation and cancer
Steven R. Barthel et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2007)
Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis
Julie Decock et al.
CANCER RESEARCH (2007)
Tumour micro environment -: Opinion -: Emerging roles of proteases in tumour suppression
Carlos LOpez-Otin et al.
NATURE REVIEWS CANCER (2007)
Bortezomib for the treatment of mantle cell lymphoma
Robert C. Kane et al.
CLINICAL CANCER RESEARCH (2007)
Cell motility and cytoskeletal regulation in invasion and metastasis
Dmitriy Kedrin et al.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2007)
Mechanical force modulates global gene expression and β-catenin signaling in colon cancer cells
Christopher L. Avvisato et al.
JOURNAL OF CELL SCIENCE (2007)
Expression of collagenase-1 (MMP-1) promotes melanoma growth through the generation of active transforming growth factor-β
Joji Iida et al.
MELANOMA RESEARCH (2007)
Fascin, a novel target of β-Catenin-TCF signaling, is expressed at the invasive front of human colon cancer
Danijela Vignjevic et al.
CANCER RESEARCH (2007)
A phase I trial of sorafenib (BAY 43-9006) for patients with recurrent or progressive malignant glioma (NABTT 0401)
L. B. Nabors et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
Increased tumor cell dissemination and cellular senescence in the absence of β1-integrin function
Angelika Kren et al.
EMBO JOURNAL (2007)
ICAM-1 expression determines malignant potential of cancer
Christina L. Roland et al.
SURGERY (2007)
Tumor-associated macrophages press the angiogenic switch in breast cancer
Elaine Y. Lin et al.
CANCER RESEARCH (2007)
A phase I study of thalidomide, capecitabine and temozolomide in advanced cancer
Damian A. Laber et al.
CANCER BIOLOGY & THERAPY (2007)
Interaction between cancer cells and stromnal fibroblasts is required for activation of the uPAR-uPA-NMP-2 cascade in pancreatic cancer metastasis
Yu He et al.
CLINICAL CANCER RESEARCH (2007)
Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
Maximilian Bockhorn et al.
LANCET ONCOLOGY (2007)
Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma
L. Burt Nabors et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis
Robert R. Langley et al.
ENDOCRINE REVIEWS (2007)
The host inflammatory response promotes liver metastasis by increasing tumor cell arrest and extravasation
Patrick Auguste et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia
Emily S. Clark et al.
CANCER RESEARCH (2007)
Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors
Weigang Wang et al.
CANCER RESEARCH (2007)
Phase I evaluation of a fully human anti-αv integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors
Saifee A. Mullamitha et al.
CLINICAL CANCER RESEARCH (2007)
Matrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line
Kunrong Cheng et al.
BIOCHEMICAL PHARMACOLOGY (2007)
LPS Responsiveness and Neutrophil Chemotaxis In Vivo Require PMN MMP-8 Activity
Angus M. Tester et al.
PLOS ONE (2007)
Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
Jeffrey B. Wyckoff et al.
CANCER RESEARCH (2007)
Kinetic-structural analysis of neuronal growth cone veil motility
Anne K. Mongiu et al.
JOURNAL OF CELL SCIENCE (2007)
Clinical significance of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric cancer
Ki-Nam Shim et al.
JOURNAL OF GASTROENTEROLOGY (2007)
Angiogenic effect of intercellular adhesion molecule-1
Deng Chenguo et al.
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2007)
Emerging roles of cysteine cathepsins in disease and their potential as drug targets
Olga Vasiljeva et al.
CURRENT PHARMACEUTICAL DESIGN (2007)
SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion
Takanori Kitamura et al.
NATURE GENETICS (2007)
Effects of extracellular fiber architecture on cell membrane shear stress in a 3D fibrous matrix
John A. Pedersen et al.
JOURNAL OF BIOMECHANICS (2007)
Multifaceted roles of Integrins in breast cancer metastasis
Donald E. White et al.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2007)
Getting to the site of inflammation: the leukocyte adhesion cascade updated
Klaus Ley et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Opinion - Angiogenesis: an organizing principle for drug discovery?
Judah Folkman
NATURE REVIEWS DRUG DISCOVERY (2007)
The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasis
Jianhua Wang et al.
CANCER AND METASTASIS REVIEWS (2006)
Direct targeting of αvβ3 integrin on tumor cells with a monoclonal antibody, Abegrin™
Kathy Mulgrew et al.
MOLECULAR CANCER THERAPEUTICS (2006)
CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas
Navid Redjal et al.
CLINICAL CANCER RESEARCH (2006)
A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus
Bernard M. Tijink et al.
CLINICAL CANCER RESEARCH (2006)
Selectins and glycosyltransferases in leukocyte rolling in vivo
Markus Sperandio
FEBS JOURNAL (2006)
Urokinase induces activation of STAT3 in lung epithelial cells
Sreerama Shetty et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2006)
Cysteine cathepsins: multifunctional enzymes in cancer
Mona Mostafa Mohamed et al.
NATURE REVIEWS CANCER (2006)
Death receptor-3, a new E-selectin counter-receptor that confers migration and survival advantages to colon carcinoma cells by triggering p38 and ERK MAPK activation
Stephanie Gout et al.
CANCER RESEARCH (2006)
Epilysin (MMP-28) induces TGF-β mediated epithelial to mesenchymal transition in lung carcinoma cells
Sara A. Illman et al.
JOURNAL OF CELL SCIENCE (2006)
Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP
A. G. Remacle et al.
ONCOGENE (2006)
A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo
Parisa Khalili et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Organ-specific metastatic tumor cell adhesion and extravasation of colon carcinoma cells with different metastatic potential
Kerstin Schlueter et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis
Hiroaki Nozawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metal loproteinase-12 in non-small cell lung cancer
Heath B. Acuff et al.
CANCER RESEARCH (2006)
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo
Jeffrey B. Wyckoff et al.
CURRENT BIOLOGY (2006)
Matrix metalloproteinase-8: Cleavage can be decisive
Philippe Van Lint et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2006)
Tumor metastasis: mechanistic insights and clinical challenges
Patricia S. Steeg
NATURE MEDICINE (2006)
Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation
Tobias Goerge et al.
CANCER RESEARCH (2006)
Functions of CXCL12 and CXCR4 in breast cancer
Kathryn E. Luker et al.
CANCER LETTERS (2006)
Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer
M. Z. Dewan et al.
BIOMEDICINE & PHARMACOTHERAPY (2006)
Cathepsin D:: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis
Emmanuelle Liaudet-Coopman et al.
CANCER LETTERS (2006)
Macrophage elastase (matrixmetalloproteinase-12) suppresses growth of lung metastases
A. McGarry Houghton et al.
CANCER RESEARCH (2006)
Clinical patterns of metastasis
Stanley P. L. Leong et al.
CANCER AND METASTASIS REVIEWS (2006)
Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor
RD Bonfil et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Matrix metalloproteinase-13 expression is associated with bone marrow microinvolvement and prognosis in non-small cell lung cancer
Chung-Ping Hsu et al.
LUNG CANCER (2006)
HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells
Monica M. Burdick et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
United States Food and Drug Administration approval summary: Bortezomib for the treatment of progressive multiple myeloma after one prior therapy
Robert C. Kane et al.
CLINICAL CANCER RESEARCH (2006)
Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow
Jerry S. H. Lee et al.
JOURNAL OF CELL SCIENCE (2006)
Lymphatic or hematogenous dissemination: How does a metastatic tumor cell decide?
Sunny Y. Wong et al.
CELL CYCLE (2006)
Invadopodia and podosomes in tumor invasion
H Yamaguchi et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2006)
Inflammation, proteases and cancer
LCL van Kempen et al.
EUROPEAN JOURNAL OF CANCER (2006)
Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer
WJ Lubbe et al.
CLINICAL CANCER RESEARCH (2006)
Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: Defining the stages of invadopodia formation and function
VV Artym et al.
CANCER RESEARCH (2006)
Antiangiogenesis in cancer therapy - endostatin and its mechanisms of action
J Folkman
EXPERIMENTAL CELL RESEARCH (2006)
Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L
D Baechle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Neutrophils and immunity: challenges and opportunities
C Nathan
NATURE REVIEWS IMMUNOLOGY (2006)
Association between high collagenase-3 expression levels and poor prognosis in patients with head and neck cancer
M Luukkaa et al.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2006)
Matrix metalloproteinases and tumor metastasis
EI Deryugina et al.
CANCER AND METASTASIS REVIEWS (2006)
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
JA Burger et al.
BLOOD (2006)
Phase I/II trial assessing bortezomlb and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma
JR Berenson et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Structure and function of matrix metalloproteinases and TIMPs
H Nagase et al.
CARDIOVASCULAR RESEARCH (2006)
Complex networks orchestrate epithelial-mesenchymal transitions
JP Thiery et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
J Condeelis et al.
CELL (2006)
Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis
CS Xue et al.
CANCER RESEARCH (2006)
Targeting proteases: successes, failures and future prospects
Boris Turk
NATURE REVIEWS DRUG DISCOVERY (2006)
Monocyte and macrophage heterogeneity
S Gordon et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Hypoxia of endothelial cells leads to MMP-2-dependent survival and death
Y Ben-Yosef et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2005)
Phase I trial of a monoclonal antibody specific for αvβ3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion
DG McNeel et al.
CLINICAL CANCER RESEARCH (2005)
Rho GTPases and the control of cell behaviour
A Hall
BIOCHEMICAL SOCIETY TRANSACTIONS (2005)
Macrophages direct tumour histology and clinical outcome in a colon cancer model
SJ Oosterling et al.
JOURNAL OF PATHOLOGY (2005)
IKK/NF-κB signaling: balancing life and death -: a new approach to cancer therapy
JL Luo et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Pathophysiological consequences of VEGF-induced vascular permeability
SM Weis et al.
NATURE (2005)
TGF-β and epithelial-to-mesenchymal transitions
J Zavadil et al.
ONCOGENE (2005)
Breast cancer metastasis: Markers and models
B Weigelt et al.
NATURE REVIEWS CANCER (2005)
Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor
M Jordà et al.
JOURNAL OF CELL SCIENCE (2005)
Regulation of cadherin-mediated adhesion in morphogenesis
BM Gumbiner
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Functional characterization of neostatins, the MMP-derived, enzymatic cleavage products of type XVIII collagen
JH Chang et al.
FEBS LETTERS (2005)
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and, β-catenin translocation
T Maretzky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment
DA Sipkins et al.
NATURE (2005)
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop
S Goswami et al.
CANCER RESEARCH (2005)
Proteasome: an emerging target for cancer therapy
I Zavrski et al.
ANTI-CANCER DRUGS (2005)
Breast cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-α and TGF-β
CH Stuelten et al.
JOURNAL OF CELL SCIENCE (2005)
Matrix metal loproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis
GA Limb et al.
AMERICAN JOURNAL OF PATHOLOGY (2005)
Antimetastatic activity of a novel mechanism-based gelatinase inhibitor
A Krüger et al.
CANCER RESEARCH (2005)
Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues
LA Ebert et al.
MOLECULAR IMMUNOLOGY (2005)
Matrix metalloproteinase 19 processes the laminin 5 gamma 2 chain and induces epithelial cell migration
T Sadowski et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion
S Wilkinson et al.
NATURE CELL BIOLOGY (2005)
Phase I/II study of immunotherapy with T-cell peptide epitopes in patients with stage IV melanoma
P Hersey et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2005)
Molecular insights into prostate cancer progression: The missing link of tumor microenvironment
LWK Chung et al.
JOURNAL OF UROLOGY (2005)
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
T Yeung et al.
CELL MOTILITY AND THE CYTOSKELETON (2005)
Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin γ2 chain
N Koshikawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
ECM degrading proteases and tissue remodelling in the mammary gland
KA Green et al.
BIOESSAYS (2005)
Adams: Key components in EGFR signalling and development
CP Blobel
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Intercellular adhesion molecule-1 (ICAM-1) regulates endothelial cell motility through a nitric oxide-dependent pathway
CG Kevil et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Endothelial P-selectin as a target of heparin action in experimental melanoma lung metastasis
RJ Ludwig et al.
CANCER RESEARCH (2004)
Differential gene expression in metastasizing cells shed from kidney tumors
M Bockhorn et al.
CANCER RESEARCH (2004)
Cysteine proteases as disease markers
I Berdowska
CLINICA CHIMICA ACTA (2004)
Cellular mechanisms of direct-current electric field effects: galvanotaxis and metastatic disease
ME Mycielska et al.
JOURNAL OF CELL SCIENCE (2004)
TIMPs as multifacial proteins
E Lambert et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2004)
Integrins: roles in cancer development and as treatment targets
H Jin et al.
BRITISH JOURNAL OF CANCER (2004)
The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells
DV Rozanov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
U Cavallaro et al.
NATURE REVIEWS CANCER (2004)
Prespecification and plasticity: shifting mechanisms of cell migration
P Friedl
CURRENT OPINION IN CELL BIOLOGY (2004)
Integrin signalling during tumour progression
WJ Guo et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-β or wounding
O De Wever et al.
JOURNAL OF CELL SCIENCE (2004)
Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion
T Korb et al.
EXPERIMENTAL CELL RESEARCH (2004)
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation
G Mouneimne et al.
JOURNAL OF CELL BIOLOGY (2004)
Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
S Douma et al.
NATURE (2004)
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells -: Role of BRAF mutation and fibroblast growth factor signaling
JT Huntington et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cancer genes and the pathways they control
B Vogelstein et al.
NATURE MEDICINE (2004)
Tumour-stroma interaction:: cancer-associated fibroblasts as novel targets in anti-cancer therapy?
P Micke et al.
LUNG CANCER (2004)
Circulating tumor cells in patients with breast cancer dormancy
SD Meng et al.
CLINICAL CANCER RESEARCH (2004)
Apatite-mediated actin dynamics in resorbing osteoclasts
F Saltel et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Platelet-cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation
P Jurasz et al.
BRITISH JOURNAL OF PHARMACOLOGY (2004)
MMP-2 plays an essential role in producing epithelial-mesenchymal transformations in the avian embryo
TD Duong et al.
DEVELOPMENTAL DYNAMICS (2004)
Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: Quantitative analysis with firefly luciferase-expressing melanoma cells
K Hyoudou et al.
CLINICAL CANCER RESEARCH (2004)
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway
SE Tague et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
CNTO 95, a fully human monoclonal antibody that inhibits αv integrins, has antitumor and antiangiogenic activity in vivo
M Trikha et al.
INTERNATIONAL JOURNAL OF CANCER (2004)
Anti-invasive, antitumoral, and antiangiogenic efficacy of a pyrimidine-2,4,6-trione derivative, an orally active and selective matrix metalloproteinases inhibitor
E Maquoi et al.
CLINICAL CANCER RESEARCH (2004)
MEROPS: the peptidase database
ND Rawlings et al.
NUCLEIC ACIDS RESEARCH (2004)
Vascular zip codes in angiogenesis and metastasis
E Ruoslahti
BIOCHEMICAL SOCIETY TRANSACTIONS (2004)
Cysteine cathepsins in human cancer
C Jedeszko et al.
BIOLOGICAL CHEMISTRY (2004)
Ligands for L-selectin: Homing, inflammation, and beyond
SD Rosen
ANNUAL REVIEW OF IMMUNOLOGY (2004)
Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis
S Weis et al.
JOURNAL OF CELL BIOLOGY (2004)
The three Es of cancer immunoediting
GP Dunn et al.
ANNUAL REVIEW OF IMMUNOLOGY (2004)
Decreased secretion of Cathepsin D in breast cancer in vivo by tamoxifen:: mediated by the mannose-6-phosphate/IGF-II receptor?
C Dabrosin et al.
BREAST CANCER RESEARCH AND TREATMENT (2004)
A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors
J Wyckoff et al.
CANCER RESEARCH (2004)
Integrins: Structure and signaling
AE Berman et al.
BIOCHEMISTRY-MOSCOW (2003)
Intravital imaging of cell movement in tumours
J Condeelis et al.
NATURE REVIEWS CANCER (2003)
Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development
CV Hojilla et al.
BRITISH JOURNAL OF CANCER (2003)
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice
M Balbín et al.
NATURE GENETICS (2003)
Lymphangiogenesis and tumor metastasis
MS Pepper et al.
CELL AND TISSUE RESEARCH (2003)
Glycan-dependent leukocyte adhesion and recruitment in inflammation
JB Lowe
CURRENT OPINION IN CELL BIOLOGY (2003)
Axis of evil: molecular mechanisms of cancer metastasis
T Bogenrieder et al.
ONCOGENE (2003)
Activated integrin αvβ3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells
M Rolli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
E Sahai et al.
NATURE CELL BIOLOGY (2003)
Membrane proteins with immunoglobulin-like domains - a master superfamily of interaction molecules
AN Barclay
SEMINARS IN IMMUNOLOGY (2003)
Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by MAP kinases, AP-1, and NF-κB transcription factors in articular chondrocytes
A Liacini et al.
EXPERIMENTAL CELL RESEARCH (2003)
Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix
KB Hotary et al.
CELL (2003)
Membrane anchored serine proteases: A rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer
S Netzel-Arnett et al.
CANCER AND METASTASIS REVIEWS (2003)
The role of selectins in inflammation and disease
K Ley
TRENDS IN MOLECULAR MEDICINE (2003)
MHC class I antigens, immune surveillance, and tumor immune escape
A Garcia-Lora et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2003)
Tumour-cell invasion and migration: Diversity and escape mechanisms
P Friedl et al.
NATURE REVIEWS CANCER (2003)
Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population
IJ Fidler et al.
NATURE GENETICS (2003)
RGD peptides released from βig-h3, a TGF-β-induced cell-adhesive molecule, mediate apoptosis
JE Kim et al.
ONCOGENE (2003)
Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow
MM Burdick et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)
Overexpression of cadherins suppresses pulmonary metastasis of osteosarcoma in vivo
T Kashima et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis
RS Watnick et al.
CANCER CELL (2003)
Cellular motility driven by assembly and disassembly of actin filaments
TD Pollard et al.
CELL (2003)
Co-cultivation of pancreatic cancer cells with orthotopic tumor-derived fibroblasts: fibroblasts stimulate tumor cell invasion via HGF secretion whereas cancer cells exert a minor regulative effect on fibroblasts HGF production
LW Qian et al.
CANCER LETTERS (2003)
Platelet-endothelial cell adhesion molecule-1 modulates endothelial migration through its immunoreceptor tyrosine-based inhibitory motif
D Gratzinger et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Compensation mechanism in tumor cell migration:: mesenchymal-amoeboid transition after blocking of pericellular proteolysis
K Wolf et al.
JOURNAL OF CELL BIOLOGY (2003)
Early combined treatment with carboplatin and the MMP inhibitor, prinomastat, prolongs survival and reduces systemic metastasis in an aggressive orthotopic lung cancer model
J Liu et al.
LUNG CANCER (2003)
Phosphoinositide regulation of the actin cytoskeleton
HL Yin et al.
ANNUAL REVIEW OF PHYSIOLOGY (2003)
c-Met: Structure, functions and potential for therapeutic inhibition
PC Ma et al.
CANCER AND METASTASIS REVIEWS (2003)
Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma
M Kato et al.
BREAST CANCER RESEARCH (2003)
CD44: From adhesion molecules to signalling regulators
H Ponta et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Synthesis and evaluation of anticancer benzoxazoles and benzimidazoles related to UK-1
D Kumar et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2002)
A novel role for p120 catenin in E-cadherin function
RC Ireton et al.
JOURNAL OF CELL BIOLOGY (2002)
Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury
A Cho et al.
CIRCULATION RESEARCH (2002)
Chemokines, chemokine receptors and small-molecule antagonists: recent developments
JJ Onuffer et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2002)
Selectins: lectins that initiate cell adhesion under flow
RP McEver
CURRENT OPINION IN CELL BIOLOGY (2002)
Integrins: Bidirectional, allosteric signaling machines
RO Hynes
CELL (2002)
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling
J Takagi et al.
CELL (2002)
Dissemination and growth of cancer cells in metastatic sites
AF Chambers et al.
NATURE REVIEWS CANCER (2002)
Protease degradomics:: A new challenge for proteomics
C López-Otin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Cadherin and catenin alterations in human cancer
KM Hajra et al.
GENES CHROMOSOMES & CANCER (2002)
A novel PKC-regulated mechanism controls CD44-ezrin association and directional cell motility
JW Legg et al.
NATURE CELL BIOLOGY (2002)
Loss of cell anchorage triggers apoptosis (anoikis) in primary mouse hepatocytes
FN Smets et al.
MOLECULAR GENETICS AND METABOLISM (2002)
Tumor-associated macrophages in breast cancer
RD Leek et al.
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2002)
High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma
J Nikkola et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
Role of integrins in cell invasion and migration
JD Hood et al.
NATURE REVIEWS CANCER (2002)
Urokinase as a multidomain protein and polyfunctional cell regulator
VV Stepanova et al.
BIOCHEMISTRY-MOSCOW (2002)
Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines
P Heikkila et al.
ANTI-CANCER DRUGS (2002)
New functions for the matrix metalloproteinases in cancer progression
M Egeblad et al.
NATURE REVIEWS CANCER (2002)
The seed and soil hypothesis: vascularisation and brain metastases
IJ Fidler et al.
LANCET ONCOLOGY (2002)
Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
GA McQuibban et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Molecular architecture of adherens junctions
A Nagafuchi
CURRENT OPINION IN CELL BIOLOGY (2001)
Activation of ADAM 12 protease by copper
F Loechel et al.
FEBS LETTERS (2001)
Lysosomal cysteine proteases: facts and opportunities
V Turk et al.
EMBO JOURNAL (2001)
Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis
MS Pepper
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2001)
Inhibition of NF-κB activity by thalidomide through suppression of IκB kinase activity
JA Keifer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The microenvironment of the tumour-host interface
LA Liotta et al.
NATURE (2001)
Urokinase receptor and fibronectin regulate the ERKMAPK to p38MAPK activity ratios that determine carcinoma cell proliferation or dormancy in vivo
JA Aguirre-Ghiso et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Angiomotin:: An angiostatin binding protein that regulates endothelial cell migration and tube formation
B Troyanovsky et al.
JOURNAL OF CELL BIOLOGY (2001)
Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2
ZT Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Involvement of chemokine receptors in breast cancer metastasis
A Müller et al.
NATURE (2001)
Overexpression of CD44 variant 6 in human endometrial cancer and its prognostic significance
A Ayhan et al.
GYNECOLOGIC ONCOLOGY (2001)
Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor
H Khoury et al.
ONCOGENE (2001)
Development of matrix metalloproteinase inhibitors in cancer therapy
M Hidalgo et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2001)
A role for N-cadherin in the development of the differentiated osteoblastic phenotype
SL Ferrari et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2000)
Mechanisms of tumor metastasis: cell biological aspects and clinical implications
R Engers et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2000)
Focal adhesions: A nexus for intracellular signaling and cytoskeletal dynamics
SK Sastry et al.
EXPERIMENTAL CELL RESEARCH (2000)
Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth
L Ossowski et al.
CURRENT OPINION IN CELL BIOLOGY (2000)
Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation
JJ Caterina et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3
GA McQuibban et al.
SCIENCE (2000)
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation
IRG Beavon
EUROPEAN JOURNAL OF CANCER (2000)
Ligand binding to integrins
EF Plow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors
MY Hsu et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization
A Pozzi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis
RB Hazan et al.
JOURNAL OF CELL BIOLOGY (2000)
Unraveling the role of proteases in cancer
JE Koblinski et al.
CLINICA CHIMICA ACTA (2000)
Regulation of cadherin adhesive activity
BM Gumbiner
JOURNAL OF CELL BIOLOGY (2000)
Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5
N Koshikawa et al.
JOURNAL OF CELL BIOLOGY (2000)
Prinomastat, a hydroxamate-based matrix metalloproteinase inhibitor. A novel pharmacological approach for tissue remodelling-related diseases
R Scatena
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2000)
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