期刊
TUMOR BIOLOGY
卷 36, 期 4, 页码 2377-2381出版社
SPRINGER
DOI: 10.1007/s13277-014-2845-5
关键词
Prostatic cancer; Ginsenoside Rh2; Transforming growth factor beta receptor signaling; SMAD2
类别
Ginsenoside Rh2 (GRh2) has been reported to have therapeutic effects on some types of cancer, but its effect on prostatic cancer has not been extensively evaluated. Here, we show that GRh2 can substantially inhibit the growth of prostatic cancer in vivo and in vitro. Moreover, the inhibition of the tumor growth appeared to result from a combined inhibitory effect on tumor cell proliferation and tumor cell invasiveness. Further analyses suggest that GRh2 seemed to activate transforming growth factor beta (TGF beta) receptor signaling in prostatic cancer cells, which subsequently inhibits cell proliferation and invasion through regulating cell-cycle controllers and (MMPs), respectively. Taken together, our data reveal an essential anti-prostatic cancer effect of GRh2 and demonstrate that this effect is through augment of TGF beta receptor signaling in the prostatic cancer cells. GRh2 thus appears to be a promising therapy for prostatic cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据