4.1 Article

Cell growth inhibition in HPV 18 positive uveal melanoma cells by E6/E7 siRNA

期刊

TUMOR BIOLOGY
卷 34, 期 3, 页码 1801-1806

出版社

SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-013-0719-x

关键词

Uveal melanoma; Human papillomavirus 18; E6; E7; siRNA

类别

资金

  1. National Key Program for Basic Research of China [2010CB529902]
  2. National Natural Science Foundation of China [81172323, 31200632]
  3. Science and Technology Commission of Shanghai [10JC1409100, 12ZR1417300]
  4. Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01040411]
  5. Shanghai Rising-Star Program [11QA1404000]

向作者/读者索取更多资源

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. However, the molecular development of UM is not fully understood and current therapeutic modalities result in poor outcomes. Increasingly, data have shown that human papillomaviruses (HPVs) contribute to the development of cervical cancer and other malignancies, and the key viral oncoprotein E6/E7 has become the target of gene therapy in HPV-related cancers. In this study, we identified HPV 18 infection in the UM cell line, VUP, for the first time and silenced HPV 18 E6/E7 expression using siRNA. Our results demonstrated that down regulation of HPV 18E6/E7 led to growth inhibition and cell cycle block in VUP cells by activation of the p53 and Rb pathways. We propose that HPV is possibly involved in the development of UM, and provide a novel target for the development of therapeutic strategies for UM.

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