期刊
TUMOR BIOLOGY
卷 33, 期 3, 页码 573-590出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-011-0286-y
关键词
Radioimmunotherapy; Alpha particles; Antibody; Actinium; Astatine; Bismuth; Lead; Radium; Thorium; Alpha targeted therapy; Alpha emitters
类别
资金
- NIH
- National Cancer Institute
- Center for Cancer Research
The effectiveness of targeted alpha-therapy (TAT) can be explained by the properties of alpha-particles. Alpha particles are helium nuclei and are similar to 8,000 times larger than beta(-)-particles (electrons). When emitted from radionuclides that decay via an alpha-decay pathway, they release enormous amounts of energy over a very short distance. Typically, the range of alpha-particles in tissue is 50-100 mu m and they have high linear energy transfer (LET) with a mean energy deposition of 100 keV/mu m, providing a more specific tumor cell killing ability without damage to the surrounding normal tissues than beta(-)-emitters. Due to these properties, the majority of pre-clinical and clinical trials have demonstrated that alpha-emitters such as Ac-225, At-211, Bi-212, Bi-213, Pb-212, Ra-223, and Th-227 are ideal for the treatment of smaller tumor burdens, micrometastatic disease, and disseminated disease. Even though these alpha-emitters have favorable properties, the development of TAT has been limited by high costs, unresolved chemistry, and limited availability of the radionuclides. To overcome these limitations, more potent isotopes, additional sources, and more efficient isotope production methods should be addressed. Furthermore, better chelation and labeling methods with the improvements of isotope delivery, targeting vehicles, molecular targets, and identification of appropriate clinical applications are still required.
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