期刊
TUMOR BIOLOGY
卷 30, 期 4, 页码 171-175出版社
SAGE PUBLICATIONS LTD
DOI: 10.1159/000236409
关键词
Breast cancer; Estrogen receptor-alpha; Estrogen receptor-beta; Prognosis, breast cancer
类别
资金
- Health Research Board of Ireland
Background/Aims: Estrogen receptor (ER) is the prototype therapy predictive marker in oncology. The ER is now known to exist in two main forms with similar overall structure: ER-alpha and ER-beta. Both forms may be expressed in breast cancer. The aim of this study was to examine breast cancer outcome in relation to expression of ER-beta. Methods: In this investigation, we measured the expression of ER-alpha protein and ER-beta mRNA in 121 extracts of invasive breast cancer. Association of expression with clinical outcome was examined using Kaplan-Meier and Cox regression analyses. Results: While ER-alpha expression was associated with good patient outcome [hazard ratio (HR) for death from breast cancer 0.37; 95% confidence interval (CI) 0.17-0.84; p = 0.017], ER-beta predicted poor outcome (HR for death from breast cancer 2.49; 95% CI 1.10-5.63; p = 0.028). Conclusion: Based on these findings, we conclude that ER-beta may have a different biological role from that of ER-alpha in breast cancer. Copyright (C) 2009 S. Karger AG, Basel
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