期刊
TUBERCULOSIS
卷 94, 期 6, 页码 538-543出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2014.08.002
关键词
Metabolomics; Adaptive metabolism; Cell cycle
资金
- Stony Wold Herbert Fund
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB) and second leading cause of human mortality due to a single infectious agent. This is mostly because of M. tuberculosis' ability to adapt its metabolism to the host environment and regulate entry into and exit from cell cycle. Knowledge of the specific metabolic changes accompanying these transitions however is incomplete. Metabolomics has emerged as a new biochemical window into M. tuberculosis physiology. This review highlights recent insights from the application of such technologies to studies of the M. tuberculosis lifecycle. (C) 2014 Elsevier Ltd. All rights reserved.
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