期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 4, 期 10, 页码 1103-1111出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201500224
关键词
2-bromobenzylamine; copper; cyclization; nitrogen heterocycles; tetrahydrobenzodiazepines
资金
- IIT-Kanpur
- CSIR, India
- UGC, India
A synthetic route to 2,3,4,5-tetrahydrobenzodiazepines has been devised through an S(N)2-type ring-opening of N-activated aziridines with 2-bromobenzylamine followed by an intramolecular cyclization through Cu-powder-mediated C-N bond formation. This operationally simple and extremely stereospecific ring-opening-cyclization approach is very efficient for the synthesis of a diverse array of the desired benzodiazepine derivatives in excellent yields of up to 94% and enantiomeric excess of up to >99%.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据