期刊
TUBERCULOSIS
卷 89, 期 5, 页码 354-363出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.tube.2009.07.006
关键词
MLSCN; TAACF; Antitubercular; High-throughput screening; Medicinal chemistry analysis; Small molecule chemical library; Tuberculosis
资金
- National Institutes of Health [1U54-HG-003917]
- Southern Research Molecular Libraries Screening Center
- NIH TAACF [N01-AI-95364]
There is an urgent need for the discovery and development of new antitubercular agents that target novel biochemical pathways and treat drug-resistant forms of the disease. One approach to addressing this need is through high-throughput screening of drug-like small molecule libraries against the whole bacterium in order to identify a variety of new, active scaffolds that will stimulate additional biological research and drug discovery. Through the Molecular Libraries Screening Center Network, the NIAID Tuberculosis Antimicrobial Acquisition and Coordinating Facility tested a 215,110-compound library against Mycobacterium tuberculosis strain H37Rv. A medicinal chemistry survey of the results from the screening campaign is reported herein. (C) 2009 Elsevier Ltd. All rights reserved.
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