期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 5, 期 1, 页码 91-97出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201500344
关键词
aldehydes; [4+1] cycloaddition; domino reactions; imidazo[2,1-b][1,3]thiazin-5-ones; thiourea
资金
- MHRD
A multicomponent domino reaction of thiourea, alkyl propiolates, aldehydes, and isocyanides has been established, providing direct access to 2-aryl-5H-imidazo[2,1-b][1,3]thiazin-5-one scaffolds. The simplicity of execution, readily available substrates, cheap reagents, high yields, excellent functional group tolerance, scalability, and good scores of environmental parameters make this synthetic strategy more efficient and worthy of further attention.
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