期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 44, 期 8, 页码 1933-1937出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/21691401.2015.1111238
关键词
Bifidobacterium longum; inflammasome; NLRP3; postinfectious irritable bowel syndrome
We aimed to explore the role of NLRP3 inflammasome in Bifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome (PI-IBS). Fifty NIH mice were divided into five groups (n=10). The visceral sensitivities of PI-2W and PI-8W groups significantly exceeded than those of normal control groups (P<0.05), which was significantly decreased in PI-B group (P<0.05). Significantly more IL-18 and IL-1 were expressed in PI-2W and PI-8W groups than those in normal control groups (P<0.05), which was significantly decreased in PI-B group (P<0.05). Bifidobacterium longum may down-regulate IL-18 and IL-1 expressions by inhibiting NLRP3 inflammasome and thus reduce the visceral hypersensitivity of PI-IBS.
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