期刊
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
卷 13, 期 11, 页码 1833-1836出版社
PHARMACOTHERAPY GROUP
DOI: 10.4314/tjpr.v13i11.9
关键词
alpha-Glucosidase; Inhibition; Diabetes; Acarbose; Croton bonplandianum
Purpose: To evaluate the alpha-glucosidase inhibitory activity of Croton bonplandianum Baill as a probable remedy for the management of diabetes. Methods: Dichloromethane and methanol extracts were prepared and screened for their alpha-glucosidae inhibitory activity using standard in vitro alpha-glucosidae inhibition assay. Acarbose was used as positive control. Results: alpha-Glucosidae inhibition activity of dichloromethane extract was 97.89 % with 50 % inhibitory concentration (IC50) of 14.93 mg/ml, while the methanol extract was not active. Acarbose ( reference) exhibited 92.23 % inhibition with IC50 of 38.25 mg/ml. Conclusion: The plant contains bioactive compounds with enzyme-inhibiting activity, and thus lends some support for the traditional use of this herb in the management of diabetes. Dichloromethan extract has higher alpha-glucosidase inhibition activity than the methanol extract. However, further investigation of the plant, including identification of its active components are required.
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