期刊
TRENDS IN PLANT SCIENCE
卷 19, 期 11, 页码 692-697出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tplants.2014.07.007
关键词
autophagy; cell death; development; hypersensitive response
资金
- Swedish University of Agricultural Sciences (SLU)
- Swedish Research Council (VR)
- Swedish Foundation for Strategic Research (SSF)
- Knut and Alice Wallenberg Foundation
- Olle Engkvist Foundation and Pehrssons Fund
Autophagy plays multiple, often antagonistic roles in plants. In particular, cytoprotective functions of autophagy are well balanced by cell death functions to compensate for the absence of apoptosis culminating in phagocytic clearance of dead cells. If autophagy is indeed required for plant programmed cell death (PCD), then what place does it occupy in the PCD pathways? Recent studies have examined the effects of impaired autophagy on pathogen-induced hypersensitive response (HR) and developmental PCD. While HR death was efficiently suppressed, inhibition of autophagy induced a switch from vacuolar PCD essential for development to necrosis. We therefore propose a dual role for autophagy in plant PCD: as an effector of HR PCD lying upstream of the 'point-of-no-return', and also as a downstream mechanism for clearance of terminally differentiated cells during developmental PCD.
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