期刊
TRENDS IN PLANT SCIENCE
卷 18, 期 9, 页码 496-504出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tplants.2013.04.005
关键词
cytoskeleton; microtubules; phosphatidic acid; phospholipase D; signaling
资金
- Physical Biosciences Program of the Office of Basic Energy Sciences, US Department of Energy [DE-FG02-09ER15526]
- Czech Grant Agency [GACR 13-19073S]
Plants respond to diverse biotic and abiotic stimuli as well as to endogenous developmental cues. Many of these stimuli result in altered activity of phospholipase D (PLD), an enzyme that hydrolyzes structural phospholipids producing phosphatidic acid (PA). PA is a key signaling intermediate in animals, but its targets in plants are relatively uncharacterized. Recent studies have demonstrated that the cytoskeleton is a major target of PLD-PA signaling and identified a positive feedback loop between actin turnover and PLD activity. Moreover, two cytoskeletal proteins, capping protein and MAP65-1, have been identified as PA-binding proteins regulating actin and microtubule organization and dynamics. In this review, we highlight the role of the PLD-PA module as an important hub for housekeeping and stress-induced regulation of membrane-associated cytoskeletal dynamics.
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