期刊
TRENDS IN PLANT SCIENCE
卷 17, 期 10, 页码 584-593出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tplants.2012.05.004
关键词
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资金
- National Institutes of Health (NIH) [GM-47850]
- National Science Foundation (NSF) [MCB-0929100]
- Croucher Foundation
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0929100] Funding Source: National Science Foundation
COP1 and DET1 are among the first repressors of photomorphogenesis to be identified, more than 20 years ago. Discovery of these repressors as conserved regulators of the ubiquitin-proteasome system has established protein degradation as a central theme in light signal transduction. COP1 is a RING E3 ubiquitin ligase that targets key regulators for degradation, and DET1 complexes with COP10 and DDB1, which is proposed to aid in COP1-mediated degradation. Recent studies have strengthened the role of COP1 as a major signaling center. DET1 is also emerging as a chromatin regulator in repressing gene expression. Here, we review current understanding on COP1 and DET1, with a focus on their role as part of two distinct, multimeric CUL4-based E3 ligases.
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