期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 35, 期 3, 页码 146-154出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2013.12.004
关键词
sirtuin; deacetylase; STAC; allosteric activator; aging; chromatin; diabetes; cancer; cardiovascular disease; inflammation
资金
- NIA NIH HHS [R37 AG028730, R01 AG028730, R01 AG019719] Funding Source: Medline
Recent studies in mice have identified single molecules that can delay multiple diseases of aging and extend lifespan. In theory, such molecules could prevent dozens of diseases simultaneously, potentially extending healthy years of life. In this review, we discuss recent advances, controversies, opportunities, and challenges surrounding the development of SIRT1 activators, molecules with the potential to delay aging and age-related diseases. Sirtuins comprise a family of NAID(+)-dependent deacylases that are central to the body's response to diet and exercise. New studies indicate that both natural and synthetic sirtuin activating compounds (STACs) work via a common allosteric mechanism to stimulate sirtuin activity, thereby conferring broad health benefits in rodents, primates, and possibly humans. The fact that two-thirds of people in the USA who consume multiple dietary supplements consume resveratrol, a SIRT1 activator, underscores the importance of understanding the biochemical mechanism, physiological effects, and safety of STACs.
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