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Targeting autophagy in neurodegenerative diseases

期刊

TRENDS IN PHARMACOLOGICAL SCIENCES
卷 35, 期 11, 页码 39-47

出版社

ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2014.09.002

关键词

rapamycin; mTOR; autophagy; Beclin 1; aggregation; neurodegenerative disease

资金

  1. FONDECYT [1140549, 11121524]
  2. Millennium Institute [P09-015-F]
  3. CONICYT [USA2013-0003, PAI 7912010006]
  4. ECOS-CONICYT [C13S02]
  5. Michael J. Fox Foundation for Parkinson's Research
  6. ALS Therapy Alliance
  7. Muscular Dystrophy Association
  8. Alzheimer's Disease Association
  9. Ring Initiative [ACT1109]
  10. FONDEF [D11I1007]
  11. Foundation COPEC-UC

向作者/读者索取更多资源

The most prevalent neurodegenerative disorders involve protein Autophagy is becoming an attractive target to treat neurodegenerative disorders through the selective degradation of abnormally folded proteins by the lysosomal pathway. However, accumulating evidence indicates that autophagy impairment at different regulatory steps may contribute to the neurodegenerative process. Thus, a complex scenario is emerging where autophagy may play a dual role in neurodegenerative diseases by causing the downstream effect of promoting the degradation of misfolded proteins and an upstream effect where its deregulation perturbs global proteostasis, contributing to disease progression. Challenges in the future development of therapeutic strategies to target the autophagy pathway are discussed.

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