期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 34, 期 7, 页码 361-372出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2013.05.004
关键词
nuclear receptors; ABC/SLC transporters; blood-brain barrier; transcription regulation
资金
- Natural Sciences and Engineering Research Council (NSERC-Canada)
- CIHR [MOP-56976]
ATP-binding cassette membrane-associated drug efflux transporters and solute carrier influx transporters, expressed at the blood-brain barrier, blood-cerebrospinal fluid barrier, and in brain parenchyma, are important determinants of drug disposition in the central nervous system. Targeting the regulatory pathways that govern the expression of these transporters could provide novel approaches to selectively alter drug permeability into the brain. Nuclear receptors are ligand-activated transcription factors which regulate the gene expression of several metabolic enzymes and drug efflux/influx transporters. Although efforts have primarily been focused on investigating these regulatory pathways in peripheral organs (i.e., liver and intestine), recent findings demonstrate their significance in the brain. This review addresses the role of nuclear receptors in the regulation of drug transporter functional expression in the brain. An in-depth understanding of these pathways could guide the development of novel pharmacotherapy with either enhanced efficacy in the central nervous system or minimal associated neurotoxicity.
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