期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 33, 期 5, 页码 268-272出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2012.03.007
关键词
-
资金
- [GM59957]
- [GM72970]
- [NS028471]
- [GM083118]
G-protein-coupled receptors (GPCRs) represent a large family of signaling proteins that includes many therapeutic targets; however, progress in identifying new small molecule drugs has been disappointing. The past 4 years have seen remarkable progress in the structural biology of GPCRs, raising the possibility of applying structure-based approaches to GPCR drug discovery efforts. Of the various structure-based approaches that have been applied to soluble protein targets, such as proteases and kinases, in silica docking is among the most ready applicable to GPCRs. Early studies suggest that GPCR binding pockets are well suited to docking, and docking screens have identified potent and novel compounds for these targets. This review will focus on the current state of in silica docking for GPCRs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据