期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 30, 期 2, 页码 79-84出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2008.10.008
关键词
-
资金
- [DE014928]
- [DA19585]
- [ULI RR025767]
- [DE016500]
Despite the wealth of information on cannabinoid-induced peripheral anti hyperalgesic and antinociceptive effects in many pain models, the molecular mechanism(s) for these actions remains unknown. Although metabotropic cannabinoid receptors have important roles in many pharmacological actions of cannabinoids, recent studies have led to the recognition of a family of at least five ionotropic cannabinoid receptors (ICRs). The known ICRs are members of the family of transient receptor potential (TRP) channels and include TRPV1, TRPV2, TRPV4, TRPM8 and TRPA1. Cannabinoid activation of ICRs can result in desensitization of the TRPA1 and TRPV1 channel activities, inhibition of nociceptors and anti hyperalgesia and antinociception in certain pain models. Thus, cannabinoids activate both metabotropic and ionotropic mechanisms to produce peripheral analgesic effects. Here, we provide an overview of the pharmacology of TRP channels as ICRS.
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