期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 29, 期 3, 页码 135-142出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2007.12.003
关键词
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资金
- Biotechnology and Biological Sciences Research Council [BB/E52708X/1] Funding Source: Medline
- BBSRC [BB/E52708X/1] Funding Source: UKRI
Annexin All (ANXA1) is an endogenous protein known to have potent anti-inflammatory properties in the peripheral system. It has also been detected in the brain, but its function there is still ambiguous. In this review, we have, for the first time, collated the evidence currently available on the function of ANXA1 in the brain and have proposed several possible mechanisms by which it exerts a neuroprotective or anti-neuroinflammatory function. We suggest that ANXA1, its small peptide mimetics and its receptors might be exciting new therapeutic targets in the management of a wide range of neuroinflammatory diseases, including stroke and neurodegenerative conditions.
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