期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 29, 期 5, 页码 250-257出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tips.2008.03.002
关键词
-
资金
- MRC [G0601481] Funding Source: UKRI
- Medical Research Council [G0601481] Funding Source: researchfish
- Medical Research Council [G0601481] Funding Source: Medline
- Wellcome Trust [WT082181] Funding Source: Medline
Resolution of inflammation requires the effective downregulation of key inflammatory cells such as neutrophils and eosinophils, which normally undergo programmed cell death (apoptosis) to enable their detection and removal by phagocytes such as macrophages. Dysregulation of this process is thought to contribute to the pathogenesis and progression of chronic inflammatory disorders such as chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, allergic rhinitis and inflammatory bowel disease. Importantly, knowledge of the signalling pathways responsible for the induction and execution of granulocyte apoptosis and the phagocytic removal of apoptotic cells continues to increase and, with it, the potential for incisive pharmacological intervention. In this article, we highlight pharmacological strategies that could be used to drive the resolution of inflammation by augmenting apoptosis of inflammatory cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据