期刊
TRENDS IN PARASITOLOGY
卷 34, 期 10, 页码 818-827出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2018.08.006
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- Tackling Infections to Benefit Africa, National Institute for Health Research, using Official Development Assistance (ODA) [16/136/33]
Human African trypanosomiasis (HAT) is responsible for around 3000 reported cases each year. Treatments for HAT are expensive and problematic to administer, and available drugs are old and less than ideal, some with high levels of toxicity that result in debilitating and, in some cases, fatal side effects. Treatment options are limited, with only one drug, eflornithine, introduced in the last 28 years. Here we examine the limitations of current chemotherapeutic approaches to manage HAT, the constraints to new drug development exploring drug failures and new drugs on the horizon, and consider the epidemiological, political, social, and economic factors influencing drug development.
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