期刊
TRENDS IN PARASITOLOGY
卷 34, 期 12, 页码 1038-1055出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2018.08.008
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资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) [15K19087, 18K07096]
- Research and Study Program of Tokai University Educational System General Research Organization
- AMED
- Japan International Cooperation Agency (JICA)
- Japan Agency for Medical Research and Development (AMED)
- [3308]
- [23117001]
- [23117005]
- [23390099]
- Grants-in-Aid for Scientific Research [18K07096, 15K19087] Funding Source: KAKEN
Mitochondria originated from the endosymbiotic event commencing from the engulfment of an ancestral alpha-proteobacterium by the first eukaryotic ancestor. Establishment of niches has led to various adaptations among eukaryotes. In anaerobic parasitic protists, the mitochondria have undergone modifications by combining features shared from the aerobic mitochondria with lineage-specific components and mechanisms; a diversified class of organelles emerged and are generally called mitochondrion-related organelles (MROs). In this review we summarize and discuss the recent advances in the knowledge of MROs from parasitic protists, particularly the themes such as metabolic functions, contribution to parasitism, dynamics, protein targeting, and novel lineage- specific proteins, with emphasis on the diversity among these organelles.
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