期刊
TRENDS IN PARASITOLOGY
卷 30, 期 1, 页码 12-19出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2013.10.003
关键词
coccidiosis; vaccines; chickens; food security; new approaches
类别
资金
- Biotechnology and Biological Sciences Research Council [BB/H020195/2] Funding Source: researchfish
- BBSRC [BB/H020195/2] Funding Source: UKRI
The intestinal disease coccidiosis, caused by protozoan parasites of the genus Eimeria, is one of the most important livestock diseases in the world. It has a high impact in the poultry industry where parasite transmission is favoured by high-density housing of large numbers of susceptible birds. Coccidiosis control in poultry is achieved by careful husbandry combined with in-feed anticoccidial drugs or vaccination with live parasites. However, outbreaks of coccidiosis still occur and subclinical infections, which significantly impact on productivity and food security, are common due to widespread drug resistance, high parasite prevalence, and environmental persistence. Herein, we review some recent approaches for the production of cheaper third generation vaccines, based on robust methods for identification of immunoprotective antigens and the use of transgenic Eimeria.
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