期刊
TRENDS IN PARASITOLOGY
卷 29, 期 7, 页码 346-358出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2013.04.006
关键词
-
类别
资金
- Geconcerteerde OnderzoeksActies of the Research Fund of the KU Leuven [GOA 2012/017, GOA 2013/014]
- Fund for Scientific Research
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an increasingly reported, often lethal, and incompletely understood complication of malaria. We discuss and compare the pathogenesis of MA-ARDS in patients and in different murine models, including recent models without cerebral involvement, and summarize the roles of different leukocyte subclasses, adhesion molecules, cytokines, and chemokines. In patients as well as in mice, severe edema and impaired gas exchange are associated with abundant inflammatory infiltrates consisting of mainly mononuclear cells and parasite sequestration, and the pathogenesis appears different from cerebral malaria (CM). Experimental anti-inflammatory interventions are successful in mice and remain to be validated in patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据