期刊
TRENDS IN PARASITOLOGY
卷 28, 期 11, 页码 471-478出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2012.07.007
关键词
Plasmodium falciparum; gametocyte; inner membrane complex; deformability; splenic clearance; cytoadherence
类别
资金
- ARC
- National Health Medical Research Council, Australia
- Canadian Institutes for Health Research
Plasmodium falciparum is named for the crescent or falciform shape it adopts when preparing to undergo transfer to a mosquito vector. By contrast, gametocytes of the other (less virulent) human malaria parasites retain a more rounded shape. We describe the machinery that elongates falciparum gametocytes and discuss its relation with the machinery that elongates the invasive zoites. We address the question - why do falciparum malaria gametocytes go banana-shaped? The answer may lie in the finding that gametocyte maturation is associated with an increase in cellular deformability. The shape-shifting ability of gametocytes may facilitate the sequestration of early-stage gametocytes, while enabling late-stage gametocytes to circulate in the blood stream without being removed by the mechanical filtering mechanisms in the host spleen.
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