期刊
TRENDS IN PARASITOLOGY
卷 28, 期 9, 页码 370-376出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2012.06.003
关键词
aneuploidy (experimental and natural); Leishmania; genome instability; fitness; population genetics; recombination; clonality
类别
资金
- European Commission [EC-FP7-222895]
- Flemish Ministry of Sciences (ITMA SOFT-B GeMInI)
- Baillet-Latour Foundation
Genomic stability and maintenance of the correct chromosome number are assumed to be essential for normal development in eukaryotes. Aneuploidy is usually associated with severe abnormalities and decrease of cell fitness, but some organisms appear to rely on aneuploidy for rapid adaptation to changing environments. This phenomenon is mostly described in pathogenic fungi and cancer cells. However, recent genome studies highlight the importance of Leishmania as a new model for studies on aneuploidy. Several reports revealed extensive variation in chromosome copy number, indicating that aneuploidy is a constitutive feature of this protozoan parasite genus. Aneuploidy appears to be beneficial in organisms that are primarily asexual, unicellular, and that undergo sporadic epidemic expansions, including common pathogens as well as cancer.
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